carbonic anhydrase ii — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8827	EMAC10101d		Carbonic Anhydrase
	compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an inhibitory activity in the low nanomolar range.		Carbonic Anhydrase
T0142	Brinzolamide	AL-4862	Carbonic Anhydrase
	Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.		Carbonic Anhydrase
T61982	Human carbonic anhydrase II-IN-2
	Human carbonic anhydrase II-IN-24 (Compound R-13) is a potent human carbonic anhydrase (hCA) inhibitor. Human carbonic anhydrase II-IN-24 shows K i s of 60.7, 320.7, 2298, and 35.2 nM for hCA I, II, IV and IX, respective...
T61981	Human carbonic anhydrase II-IN-1
	Human carbonic anhydrase II-IN-1 (Compound S-13) is a potent human carbonic anhydrase II (hCA II) inhibitor. Human carbonic anhydrase II-IN-1 shows Kis of 4.4 nM, 9.2 nM, 480.2 nM and 14.7 nM for hCA II, I, IV and IX, re...
T6503	Fluorometholone Acetate	NSC 47438,Flarex,Eflone,Oxylone acetate	Glucocorticoid Receptor , Carbonic Anhydrase
	Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.		Glucocorticoid Receptor , Carbonic Anhydrase
T2134	Dorzolamide hydrochloride	MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,Dorzolamide HCl	Carbonic Anhydrase
	Dorzolamide hydrochloride (MK507 hydrochloride) is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water ...		Carbonic Anhydrase
T63305	Carbonic anhydrase inhibitor 6		Carbonic Anhydrase
	Carbonic anhydrase inhibitor 6 is a potent human carbonic anhydrase (hCA) inhibitor that inhibits hCA IX, hCA II, hCA XII, and hCA I. It is used in the study of diseases caused by abnormalities in carbonic anhydrase.		Carbonic Anhydrase
T67775	Enpp/Carbonic anhydrase-IN-1		PDE , Carbonic Anhydrase
	Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 µM for NPP1, NPP2, NPP3, CA-II, CA-IX respectiv...		PDE , Carbonic Anhydrase
T67774	Compound CDy9		Carbonic Anhydrase
	Compound CDy9 is a highly selective inhibitor of carbonic anhydrase (CA) with an IC50 value of 0.18 μM for hCA II.		Carbonic Anhydrase
T0106	Methazolamide	L584601,CL 8490	Carbonic Anhydrase
	Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.		Carbonic Anhydrase
T80663	HCAI/II/IV-IN-28	WAY-638358	Carbonic Anhydrase
	hCAI/II/IV-IN-28(WAY-638358) is a potent carbonic anhydrase inhibitor with potential anticonvulsant activity.		Carbonic Anhydrase
T36758	CAIX Inhibitor S4	S4	Carbonic Anhydrase
	CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.		Carbonic Anhydrase
T61745	HCAI/II-IN-6		Carbonic Anhydrase
	hCAI/II-IN-6 is a selective and orally active inhibitor of human carbonic anhydrase (CA). hCAI/II-IN-6 inhibited hCA I, hCA II, hCA VII, and hCA XII with Ki values of 220, 4.9, 6.5, and ＞50,000 nM. hCAI/II-IN-6 showed an...		Carbonic Anhydrase
T23782	Benzolamide	CL-11366,W 1803,CL 11366,CL11366,W-1803	Carbonic Anhydrase
	Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.		Carbonic Anhydrase
T73177	HCAII-IN-9		Carbonic Anhydrase
	hCAII-IN-9 is a potent carbonic anhydrase inhibitor that inhibits hCA II, hCA IX, and hCA XII with IC50s of 1.18 μM and 0.17 μM , and 2.99 μM , respectively. hCAII-IN-9 is not blood-brain barrier permeable.		Carbonic Anhydrase
T0267	Zonisamide	AD 810,CI 912	Calcium Channel , Sodium Channel , Carbonic Anhydrase
	Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms...		Calcium Channel , Sodium Channel , Carbonic Anhydrase
T27673	JNJ-26990990		Others
	JNJ-26990990 is a broad-spectrum anticonvulsant drug as a second-generation followup to the marketed drug topiramate. It was designed to have the same anticonvulsant effects as topiramate, but without the side effects as...		Others
T0782	Benzthiazide	Aquatag,Lemazide,Dihydrex	Carbonic Anhydrase
	Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted ...		Carbonic Anhydrase
T60848	Carbonic anhydrase inhibitor 3
	Carbonic anhydrase inhibitor 3 (compound 11g) is an inhibitor of carbonic anhydrase II that reduces the intraocular pressure in glaucomatous rabbits [1].
T61120	Carbonic anhydrase inhibitor 2
	Compound 7c, identified as carbonic anhydrase inhibitor 1, effectively inhibits carbonic anhydrase II. This inhibitor, also known as carbonic anhydrase inhibitor 3, lowers intraocular pressure in glaucomatous rabbits [1]...
T61980	Carbonic anhydrase inhibitor 8
	Carbonic anhydrase inhibitor 8 (compound R-13) is a potent human carbonic anhydrase (hCA). Carbonic anhydrase inhibitor 8 shows K i values of 60.7 nM, 320.7 nM, 2298 nM for hCA I, hCA II, hCA IV, respectively.
T61292	CAII-IN-1
	CAII-IN-1 (compound 3n) is a thiosemicarbazide derivative that acts as a potent and selective inhibitor of carbonic anhydrase-II (CA-II), with an IC50 value of 10.3 μM for bovine CA-II. This compound (CAII-IN-1) finds ut...
T61340	CAII-IN-3
	CAII-IN-3 (compound 3h) is a thiosemicarbazone derivative known for its potent inhibition of carbonic anhydrase-II (CA-II). It exhibits an IC50 value of 13.4 μM [1].
T63731	Carbonic anhydrase inhibitor 9
	Carbonic anhydrase inhibitor 9 is a potent inhibitor of carbonic anhydrase (CA) that acts on hCA II (Ki: 56.4 nM) and IX (Ki: 56.9 nM) and exhibits antiproliferative effects.
T78840	Carbonic anhydrase inhibitor 15		Carbonic Anhydrase
	Carbonic Anhydrase Inhibitor 15 (Compound 8), with an inhibitory constant (K_i) of 8.5 nM for hCA II, exhibits analgesic effects [1].		Carbonic Anhydrase
T63005	Carbonic anhydrase inhibitor 11
	Carbonic anhydrase inhibitor 11 (compound VI) is a potent, selective carbonic anhydrase inhibitor that acts on CA II (Ki: 40 nM), CA IX (Ki: 39 nM) and CA XII (Ki: 900 nM).
T62976	Carbonic anhydrase inhibitor 5
	Carbonic anhydrase inhibitor 5 is a potent and selective inhibitor of human carbonic anhydrase (hCA), acting on hCA II (IC50: 42.9 nM), hCA IX (IC50: 47.6 nM) and hCA XII (IC50: 6.7 nM).
T62666	Carbonic anhydrase inhibitor 7
	Carbonic anhydrase inhibitor 7 is a potent inhibitor of human carbonic anhydrase (hCA), acting on hCA IX (Ki: 6.5 nM), hCA II (Ki: 7.1 nM), hCA XII (Ki: 72.1 nM) and hCA I (Ki: 255.8 nM).
T61842	Carbonic anhydrase inhibitor 14
	Carbonic anhydrase inhibitor 14 (Compound 8b) is a potent CA inhibitor, exhibiting K i values of 1203, 99.7, 9.4, and 27.7 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. Additionally, it effectively inhibit...
T61974	CAII-IN-2
	CAII-IN-2 (compound 3g) is a thiosemicarbazide derivative. CAII-IN-2 is a potent, selective carbonic anhydrase-II (CA-II) inhibitor with an IC50 of 12.1 μM for bovine CA-II. CAII-IN-2 has research value in carbonic anhyd...
T63467	HCAII-IN-5
	hCAII-IN-5 (compound 12h) is a potent, selective inhibitor of human carbonic anhydrase II (hCA II) with an inhibition constant (IC50) of 4.55 µM [1].
T83137	ALP/Carbonic anhydrase-IN-1		Carbonic Anhydrase
	Compound 1e, also known as ALP/Carbonic anhydrase-IN-1, is a dual inhibitor targeting both carbonic anhydrase (CA) isozymes II, IX, and XII, as well as alkaline phosphatase (ALP). It exhibits inhibitory IC50 values of 0....		Carbonic Anhydrase
T64241	Brinzolamide hydrochloride
	Brinzolamide (AL-4862) hydrochloride is a selective inhibitor (IC50: 3.2 nM) of carbonic anhydrase II. Brinzolamide hydrochloride inhibits ciliary CA-II and reduces atrial fluid secretion, thereby reducing intraocular pr...
T74587	Phenylsulfamide
	Phenylsulfamide (Compound 10), acting as an inhibitor of human carbonic anhydrase-II (hCA-II), exhibits a dissociation constant (Kd) of 45.50 μM and an inhibition constant (Ki) of 79.60 μM [1].
T61282	HCAI/II-IN-2
	hCAI/II-IN-2 (compound 2b) is a highly effective dual inhibitor of human carbonic anhydrase I and II (hCA I/II), with Ki values of 40.97 nM, 15.15 nM, and 61.88 nM for hCA I, hCA II, and hCA IX, respectively. With its an...
T62892	HCAI/II-IN-1
	hCAI/II-IN-1 (Compound 3h) is a human carbonic anhydrase I and II (hCA I/II) inhibitor that acts on hCA I (IC50: 0.047 μM) and hCA II (IC50: 0.024 μM).
T63805	β-Glucuronidase/hCAII-IN-1
	β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a compound that effectively inhibits both β-glucuronidase and human Carbonic Anhydrase II (hCA II), exhibiting IC50 values of 440.1 μM and 4.91 μM, respectively [1].
T63557	HCA I-IN-1
	hCA I-IN-1 is a human carbonic anhydrase I (hCA I) inhibitor that acts on hCA I (Ki: 38.3 nM), hCA II (Ki: 716.4 nM), hCAIX (Ki: 940.1 nM) and hCAXII (Ki: 192.8 nM).
T61164	HCAII-IN-3
	hCAII-IN-3 (Compound 16) is an inhibitor of human carbonic anhydrase (hCA). It exhibits high affinity for hCA I, hCA II, hCA IX, and hCA XII, with Ki values of 403.8 nM, 5.1 nM, 10.2 nM, and 5.2 nM, respectively. Notably...
T63908	HCAII-IN-4
	hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM. Additionally, it demonstrates inhibition of β-glucuronidase, presenting a...
T35713	N-desethyl Brinzolamide (oxalate)
	N-desethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1It inhibits CAII and CAIV activities (IC50s = 1.28 and 128 nM, respectively). 1.Kim, C.-Y., Whittington, D.A., Chang...
T63753	HCAIX-IN-3
	hCAII-IN-3 (compound 7e) is a selective and potent carbonic anhydrase (CA II/IX) inhibitors with their Kis values of 124.2 and 30.5 nM, respectively. hCAII-IN-1 has shown investigational potential for cancer disease.
T62101	HCAXII-IN-2
	hCAXII-IN-2 (compound 5i) is a potent inhibitor of human carbonic anhydrase XII (hCA XII) (Ki: 84.2 nM) and hCA IX (Ki: 268.5 nM), with low activity against hCA I and hCA II.
T63631	HCAII-IN-2
	hCAII-IN-2 is a cytoplasmic human carbonic anhydrase (hCA) inhibitor that acts on hCA I (Ki: 261.4 nM), hCA II (Ki: 3.8 nM), hCA IX (Ki: 19.6 nM) and hCA XII (Ki: 45.2 nM).
T61263	HCA IX-IN-1
	hCA IX-IN-1 (Compound 6f) is a human carbonic anhydrase ( hCA ) inhibitor with K i values of 331.4, 28.4, 9.4 and 17.8 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA IX-IN-1 shows anticancer activity [1]...
T63972	HCA I-IN-2
	hCA I-IN-2 (Compound 6d) is a selective inhibitor of human carbonic anhydrase I (hCA I) and acts on hCA I (Ki: 18.8 nM), hCA II (Ki: 375.1 nM), hCAIX (Ki: 1721 nM) and hCAXII (Ki: 283.9 nM).
T63752	HCAII-IN-1
	hCAII-IN-1 (compound 7f) is a selective and potent inhibitor of carbonic anhydrase (CA II/IX) with their Kis values of 1.2 and 113.6 nM, respectively. hCAII-IN-1 has shown investigational potential for cancer disease.
T63764	HCA XII/II/IX-IN-1
	hCA XII/II/IX-IN-1 is a potent inhibitor of human carbonic anhydrase (hCA) and is able to act on hCA I (IC50: 2.6 μM), hCA II (IC50: 0.004 μM), hCA IX (IC50: 0.005 μM) and hCA XII (IC50: 0.001 μM). hCA XII/II/IX -IN-1 ex...
T74331	HCAII-IN-7
	Compound R-13, also known as hCAII-IN-7, is a powerful inhibitor of human carbonic anhydrase (hCA), exhibiting inhibition constants (Ki) of 60.7 nM for hCA I, 320.7 nM for hCA II, 2298 nM for hCA IV, and 35.2 nM for hCA ...
T72122	Carbonic anhydrase inhibitor 12		Carbonic Anhydrase
	Carbonic Anhydrase Inhibitor 12 is a potent inhibitor of CA II, with additional inhibitory activity against CA I, exhibiting K_i values of 1.72 nM for CA II and 271 nM for CA I. Moreover, it demonstrates significant anti...		Carbonic Anhydrase

Compounds

EMAC10101d

T8827

Synonym:

Target: Carbonic Anhydrase

Brinzolamide

T0142

Synonym: AL-4862

Target: Carbonic Anhydrase

Human carbonic anhydrase II-IN-2

T61982

Synonym:

Target:

Human carbonic anhydrase II-IN-1

T61981

Synonym:

Target:

Fluorometholone Acetate

T6503

Synonym: NSC 47438,Flarex,Eflone,Oxylone acetate

Target: Glucocorticoid Receptor, Carbonic Anhydrase

Dorzolamide hydrochloride

T2134

Synonym: MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,Dorzolamide HCl

Target: Carbonic Anhydrase

Carbonic anhydrase inhibitor 6

T63305

Synonym:

Target: Carbonic Anhydrase

Enpp/Carbonic anhydrase-IN-1

T67775

Synonym:

Target: PDE, Carbonic Anhydrase

Compound CDy9

T67774

Synonym:

Target: Carbonic Anhydrase

Methazolamide

T0106

Synonym: L584601,CL 8490

Target: Carbonic Anhydrase

hCAI/II/IV-IN-28

T80663

Synonym: WAY-638358

Target: Carbonic Anhydrase

CAIX Inhibitor S4

T36758

Synonym: S4

Target: Carbonic Anhydrase

hCAI/II-IN-6

T61745

Synonym:

Target: Carbonic Anhydrase

Benzolamide

T23782

Synonym: CL-11366,W 1803,CL 11366,CL11366,W-1803

Target: Carbonic Anhydrase

hCAII-IN-9

T73177

Synonym:

Target: Carbonic Anhydrase

Zonisamide

T0267

Synonym: AD 810,CI 912

Target: Calcium Channel, Sodium Channel, Carbonic Anhydrase

Synonym: Aquatag,Lemazide,Dihydrex

Target: Carbonic Anhydrase

Carbonic anhydrase inhibitor 3

T60848

Synonym:

Target:

Carbonic anhydrase inhibitor 2

T61120

Synonym:

Target:

Carbonic anhydrase inhibitor 8

Carbonic anhydrase inhibitor 9

T63731

Synonym:

Target:

Carbonic anhydrase inhibitor 15

T78840

Synonym:

Target: Carbonic Anhydrase

Carbonic anhydrase inhibitor 11

T63005

Synonym:

Target:

Carbonic anhydrase inhibitor 5

T62976

Synonym:

Target:

Carbonic anhydrase inhibitor 7

T62666

Synonym:

Target:

Carbonic anhydrase inhibitor 14

ALP/Carbonic anhydrase-IN-1

T83137

Synonym:

Target: Carbonic Anhydrase

Brinzolamide hydrochloride

β-Glucuronidase/hCAII-IN-1

N-desethyl Brinzolamide (oxalate)

Carbonic anhydrase inhibitor 12

T72122

Synonym:

Target: Carbonic Anhydrase

Cat No.	Product Name	Synonyms	Targets
TN2095	Pomiferin		NOS , NF-κB , PDE
	Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has anti-inflammatory and neuroprotective activities.		NOS , NF-κB , PDE

Cat No.	Product Name	Species	Expression System
TMPY-01735	Carbonic Anhydrase 2 Protein, Human, Recombinant (His)	Human	E. coli
	Carbonic Anhydrase 2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30 kDa and the accession number is P00918.
TMPH-03259	Carbonic Anhydrase 2 Protein, Rat, Recombinant (His)	Rat	E. coli
	Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide abso...
TMPY-02111	Carbonic Anhydrase 2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Carbonic Anhydrase 2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30.4 kDa and the accession number is AAH55291.1.
TMPJ-00701	Carbonic Anhydrase 11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Carbonic Anhydrase-Related Protein 11 (CA11) is a secreted protein member of the α-carbonic anhydrase family. Carbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of ...

Search Result

Targets

Compounds

Natural Products

Recombinant Proteins

Compounds

Natural Products

Recombinant Proteins